Pathogen Analysis Assignment for Different Virus

April 18, 2020

Pathogen Analysis Assignment for Different Virus

Order ID 53563633773

Type Essay

Writer Level Masters

Style APA

Sources/References 4

Language English

Pages 5-10 pages

Description/Paper Instructions

As we are in the midst of a viral pandemic, please consider this assignment not only a replacement for the dreaded presentation, but also a mechanism to become more informed about the virus causing the present crisis and to practice your ability to apply basic biological concepts to a specific real-world problem.

For this assignment, you will first need to understand that the virus is called SARS-CoV-2 and infection from this virus causes a disease in humans known as COVID-19. While these are used interchangeably in the media and by most people, it is important to realize the difference. COVID-19 is not a virus, but rather a disease caused by the virus SARS-CoV-2.

You will secondly need to watch this seminar by Dr. Britt Glaunsinger.

[If the hyperlink does not work the url is: https://youtu.be/8_bOhZd6ieM?t=1 ]

I encourage you to watch the whole seminar as it is very informative and there are many opportunities to ‘see’ numerous basic molecular and cellular biology, biochemistry, and microbiology concepts. That said, the seminar is expert-level, so please also use this assignment to guide you through specific parts.

You must complete all of the questions. You may type your responses on this document or on a new word doc.

The two sets of questions begin on the next page.

Concise answers are much appreciated and indicate a good level of comprehension. `

Name:

Questions Part 1

At 10:10 of the seminar begins the discussion of virus structure and entry. Watch this part to answer the following questions.

What does it mean to have a (+) sense RNA genome and what does that indicate happens when the genome gets released into the eukaryotic cell?

Explain how CoV enters the cell. Focus on the function of the spike protein, describe the two domains and how these domains work to allow the virus to get into the cell. Don’t forget to include the “second feature” mentioned in the video for your answer and the names of any cellular receptors.

List the names of other viruses that use class 1 fusion proteins to enter the cell.

How many amino acids in the spike protein are specific for spike protein’s ability to bind to the host cell receptor?

How could mutations in the spike protein lead to increased transmission of the virus?

Questions Part 2

At 20:15 of the seminar begins the discussion of the SARS-CoV-2 genome. Watch this part to answer the following questions.

How many open reading frames and how many proteins does this virus have? Is this surprising that the number of ORFs and proteins is not the same? Why or why not.

What happens to the virus genome when it gets into the cell? (see also answer to question #1)

What does it mean that eukaryotic cells translate monocistronic mRNA? What problem does the virus face because of this rule of eukaryotic cell biology? [hint: what is the rule the ribosome follows for translation, AUG….UAA]

What is a polyprotein?

What does the “slippery sequence” allow the virus to do?

Explain how every ORF at the 3’ end of the genome can get translated and still follow the eukaryotic rule for translation? [hint: it your answer should mention the 5’ leader and capture mechanism—TRS-L] Yes, this is a hard question—do your best!

At 57:40 of the seminar is a discussion of neutralizing antibodies. Every time you are exposed to a pathogen or infection or even a vaccine, your immune system (B-cells) make antibodies that are specific for that infection. Some of these antibodies can bind to and neutralize the ability of the pathogen to infect cells. How long were neutralizing antibodies present in patients that recovered from SARS-1? What does this mean for the current SARS-CoV-2 pandemic? List the questions raised by Dr. Glaunsinger for your answer.

RUBRIC

Quality of Response No Response Poor/Unsatisfactory Satisfactory Good Excellent

Content (worth a maximum of 50% of the total points) Zero points: Student failed to submit the final paper. 20 points out of 50: The essay illustrates poor understanding of the relevant material by failing to address or incorrectly addressing the relevant content; failing to identify or inaccurately explaining/defining key concepts/ideas; ignoring or incorrectly explaining key points/claims and the reasoning behind them; and/or incorrectly or inappropriately using terminology; and elements of the response are lacking. 30 points out of 50: The essay illustrates a rudimentary understanding of the relevant material by mentioning but not full explaining the relevant content; identifying some of the key concepts/ideas though failing to fully or accurately explain many of them; using terminology, though sometimes inaccurately or inappropriately; and/or incorporating some key claims/points but failing to explain the reasoning behind them or doing so inaccurately. Elements of the required response may also be lacking. 40 points out of 50: The essay illustrates solid understanding of the relevant material by correctly addressing most of the relevant content; identifying and explaining most of the key concepts/ideas; using correct terminology; explaining the reasoning behind most of the key points/claims; and/or where necessary or useful, substantiating some points with accurate examples. The answer is complete. 50 points: The essay illustrates exemplary understanding of the relevant material by thoroughly and correctly addressing the relevant content; identifying and explaining all of the key concepts/ideas; using correct terminology explaining the reasoning behind key points/claims and substantiating, as necessary/useful, points with several accurate and illuminating examples. No aspects of the required answer are missing.

Use of Sources (worth a maximum of 20% of the total points). Zero points: Student failed to include citations and/or references. Or the student failed to submit a final paper. 5 out 20 points: Sources are seldom cited to support statements and/or format of citations are not recognizable as APA 6^th Edition format. There are major errors in the formation of the references and citations. And/or there is a major reliance on highly questionable. The Student fails to provide an adequate synthesis of research collected for the paper. 10 out 20 points: References to scholarly sources are occasionally given; many statements seem unsubstantiated. Frequent errors in APA 6^th Edition format, leaving the reader confused about the source of the information. There are significant errors of the formation in the references and citations. And/or there is a significant use of highly questionable sources. 15 out 20 points: Credible Scholarly sources are used effectively support claims and are, for the most part, clear and fairly represented. APA 6^th Edition is used with only a few minor errors. There are minor errors in reference and/or citations. And/or there is some use of questionable sources. 20 points: Credible scholarly sources are used to give compelling evidence to support claims and are clearly and fairly represented. APA 6^th Edition format is used accurately and consistently. The student uses above the maximum required references in the development of the assignment.

Grammar (worth maximum of 20% of total points) Zero points: Student failed to submit the final paper. 5 points out of 20: The paper does not communicate ideas/points clearly due to inappropriate use of terminology and vague language; thoughts and sentences are disjointed or incomprehensible; organization lacking; and/or numerous grammatical, spelling/punctuation errors 10 points out 20: The paper is often unclear and difficult to follow due to some inappropriate terminology and/or vague language; ideas may be fragmented, wandering and/or repetitive; poor organization; and/or some grammatical, spelling, punctuation errors 15 points out of 20: The paper is mostly clear as a result of appropriate use of terminology and minimal vagueness; no tangents and no repetition; fairly good organization; almost perfect grammar, spelling, punctuation, and word usage. 20 points: The paper is clear, concise, and a pleasure to read as a result of appropriate and precise use of terminology; total coherence of thoughts and presentation and logical organization; and the essay is error free.

Structure of the Paper (worth 10% of total points) Zero points: Student failed to submit the final paper. 3 points out of 10: Student needs to develop better formatting skills. The paper omits significant structural elements required for and APA 6^th edition paper. Formatting of the paper has major flaws. The paper does not conform to APA 6^th edition requirements whatsoever. 5 points out of 10: Appearance of final paper demonstrates the student’s limited ability to format the paper. There are significant errors in formatting and/or the total omission of major components of an APA 6^th edition paper. The can include the omission of the cover page, abstract, and page numbers. Additionally the page has major formatting issues with spacing or paragraph formation. Font size might not conform to size requirements. The student also significantly writes too large or too short of and paper 7 points out of 10: Research paper presents an above-average use of formatting skills. The paper has slight errors within the paper. This can include small errors or omissions with the cover page, abstract, page number, and headers. There could be also slight formatting issues with the document spacing or the font Additionally the paper might slightly exceed or undershoot the specific number of required written pages for the assignment. 10 points: Student provides a high-caliber, formatted paper. This includes an APA 6^th edition cover page, abstract, page number, headers and is double spaced in 12’ Times Roman Font. Additionally the paper conforms to the specific number of required written pages and neither goes over or under the specified length of the paper.

GET THIS PROJECT NOW BY CLICKING ON THIS LINK TO PLACE THE ORDER

https://www.perfectacademic.com/orders/ordernow

Do You Have Any Other Essay/Assignment/Class Project/Homework Related to this? Click Here Now [CLICK ME] and Have It Done by Our PhD Qualified Writers!!