Biomarker identification in metabolic diseases
Order ID |
53563633773 |
Type |
Essay |
Writer Level |
Masters |
Style |
APA |
Sources/References |
4 |
Perfect Number of Pages to Order |
5-10 Pages |
Description/Paper Instructions
Biomarker identification in metabolic diseases
Metabolic diseases, such as diabetes, obesity, and cardiovascular disease, are characterized by abnormalities in the metabolism of carbohydrates, lipids, and proteins. These diseases are complex and multifactorial, with both genetic and environmental factors contributing to their development and progression. Biomarkers are molecular or cellular indicators of disease that can be used for diagnosis, prognosis, and monitoring of disease progression. In metabolic diseases, the identification of biomarkers is critical for early detection, accurate diagnosis, and personalized treatment.
One of the most widely studied biomarkers in metabolic diseases is blood glucose levels. Elevated blood glucose levels are a hallmark of diabetes, and are used to diagnose and monitor the disease. In addition to glucose levels, other biomarkers that are commonly used in the diagnosis and monitoring of metabolic diseases include hemoglobin A1c, which provides a measure of long-term glucose control, and lipid profile, which measures levels of cholesterol and triglycerides in the blood.
Recent advances in omics technologies, such as genomics, proteomics, and metabolomics, have enabled the identification of new biomarkers for metabolic diseases. These technologies allow for the comprehensive analysis of thousands of molecules in biological samples, such as blood or urine, and can provide insights into the molecular mechanisms underlying metabolic diseases.
One example of a genomic biomarker in metabolic diseases is the presence of genetic variants that are associated with an increased risk of developing the disease. Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with metabolic diseases, such as type 2 diabetes and obesity. These genetic variants can be used to identify individuals who are at increased risk of developing the disease, and may also provide insights into the underlying molecular mechanisms.
Proteomics is another omics technology that has been used to identify biomarkers in metabolic diseases. Proteomics involves the large-scale analysis of proteins in biological samples, and can provide insights into protein expression levels, post-translational modifications, and protein-protein interactions. Several studies have identified protein biomarkers that are associated with metabolic diseases, such as adiponectin, leptin, and resistin.
Metabolomics is a rapidly evolving field that involves the analysis of small molecules, such as metabolites, in biological samples. Metabolites are the end products of cellular processes, and can provide insights into the metabolic pathways that are dysregulated in metabolic diseases. Several metabolite biomarkers have been identified in metabolic diseases, such as branched-chain amino acids, which are elevated in individuals with insulin resistance, and acylcarnitines, which are associated with mitochondrial dysfunction.
In addition to these omics technologies, machine learning algorithms can be used to identify biomarkers in metabolic diseases. Machine learning involves the use of computer algorithms to analyze large datasets and identify patterns and relationships between variables. Machine learning algorithms have been used to identify biomarkers that are associated with metabolic diseases, such as insulin resistance and type 2 diabetes.
In conclusion, the identification of biomarkers is critical for the early detection, accurate diagnosis, and personalized treatment of metabolic diseases. Advances in omics technologies, such as genomics, proteomics, and metabolomics, have enabled the identification of new biomarkers that provide insights into the underlying molecular mechanisms of metabolic diseases. In addition, machine learning algorithms can be used to analyze large datasets and identify patterns and relationships between variables. The identification of biomarkers in metabolic diseases is an active area of research, and holds promise for improving the diagnosis and treatment of these complex and multifactorial diseases.
RUBRIC
QUALITY OF RESPONSE |
NO RESPONSE |
POOR / UNSATISFACTORY |
SATISFACTORY |
GOOD |
EXCELLENT |
Content (worth a maximum of 50% of the total points) |
Zero points: Student failed to submit the final paper. |
20 points out of 50: The essay illustrates poor understanding of the relevant material by failing to address or incorrectly addressing the relevant content; failing to identify or inaccurately explaining/defining key concepts/ideas; ignoring or incorrectly explaining key points/claims and the reasoning behind them; and/or incorrectly or inappropriately using terminology; and elements of the response are lacking. |
30 points out of 50: The essay illustrates a rudimentary understanding of the relevant material by mentioning but not full explaining the relevant content; identifying some of the key concepts/ideas though failing to fully or accurately explain many of them; using terminology, though sometimes inaccurately or inappropriately; and/or incorporating some key claims/points but failing to explain the reasoning behind them or doing so inaccurately. Elements of the required response may also be lacking. |
40 points out of 50: The essay illustrates solid understanding of the relevant material by correctly addressing most of the relevant content; identifying and explaining most of the key concepts/ideas; using correct terminology; explaining the reasoning behind most of the key points/claims; and/or where necessary or useful, substantiating some points with accurate examples. The answer is complete. |
50 points: The essay illustrates exemplary understanding of the relevant material by thoroughly and correctly addressing the relevant content; identifying and explaining all of the key concepts/ideas; using correct terminology explaining the reasoning behind key points/claims and substantiating, as necessary/useful, points with several accurate and illuminating examples. No aspects of the required answer are missing. |
Use of Sources (worth a maximum of 20% of the total points). |
Zero points: Student failed to include citations and/or references. Or the student failed to submit a final paper. |
5 out 20 points: Sources are seldom cited to support statements and/or format of citations are not recognizable as APA 6th Edition format. There are major errors in the formation of the references and citations. And/or there is a major reliance on highly questionable. The Student fails to provide an adequate synthesis of research collected for the paper. |
10 out 20 points: References to scholarly sources are occasionally given; many statements seem unsubstantiated. Frequent errors in APA 6th Edition format, leaving the reader confused about the source of the information. There are significant errors of the formation in the references and citations. And/or there is a significant use of highly questionable sources. |
15 out 20 points: Credible Scholarly sources are used effectively support claims and are, for the most part, clear and fairly represented. APA 6th Edition is used with only a few minor errors. There are minor errors in reference and/or citations. And/or there is some use of questionable sources. |
20 points: Credible scholarly sources are used to give compelling evidence to support claims and are clearly and fairly represented. APA 6th Edition format is used accurately and consistently. The student uses above the maximum required references in the development of the assignment. |
Grammar (worth maximum of 20% of total points) |
Zero points: Student failed to submit the final paper. |
5 points out of 20: The paper does not communicate ideas/points clearly due to inappropriate use of terminology and vague language; thoughts and sentences are disjointed or incomprehensible; organization lacking; and/or numerous grammatical, spelling/punctuation errors |
10 points out 20: The paper is often unclear and difficult to follow due to some inappropriate terminology and/or vague language; ideas may be fragmented, wandering and/or repetitive; poor organization; and/or some grammatical, spelling, punctuation errors |
15 points out of 20: The paper is mostly clear as a result of appropriate use of terminology and minimal vagueness; no tangents and no repetition; fairly good organization; almost perfect grammar, spelling, punctuation, and word usage. |
20 points: The paper is clear, concise, and a pleasure to read as a result of appropriate and precise use of terminology; total coherence of thoughts and presentation and logical organization; and the essay is error free. |
Structure of the Paper (worth 10% of total points) |
Zero points: Student failed to submit the final paper. |
3 points out of 10: Student needs to develop better formatting skills. The paper omits significant structural elements required for and APA 6th edition paper. Formatting of the paper has major flaws. The paper does not conform to APA 6th edition requirements whatsoever. |
5 points out of 10: Appearance of final paper demonstrates the student’s limited ability to format the paper. There are significant errors in formatting and/or the total omission of major components of an APA 6th edition paper. They can include the omission of the cover page, abstract, and page numbers. Additionally the page has major formatting issues with spacing or paragraph formation. Font size might not conform to size requirements. The student also significantly writes too large or too short of and paper |
7 points out of 10: Research paper presents an above-average use of formatting skills. The paper has slight errors within the paper. This can include small errors or omissions with the cover page, abstract, page number, and headers. There could be also slight formatting issues with the document spacing or the font Additionally the paper might slightly exceed or undershoot the specific number of required written pages for the assignment. |
10 points: Student provides a high-caliber, formatted paper. This includes an APA 6th edition cover page, abstract, page number, headers and is double spaced in 12’ Times Roman Font. Additionally, the paper conforms to the specific number of required written pages and neither goes over or under the specified length of the paper. |
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Biomarker identification in metabolic diseases
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